Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Malignant giant cell tumor
Medically reviewed by Min Clinic Staff | Updated: January 2026
Malignant giant cell tumor: A type of bone tumor that is characterized by massive destruction of bone near the end (epiphysis) of a long bone and causes pain and restricts movement. The most common site of malignant giant cell tumor is the knee. Diagnosis is made by examining a sample of the affected area. Treatment involves excising the affected area, usually followed by chemotherapy or radiation.