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Definition of Tricyclic antidepressants
Medically reviewed by Min Clinic Staff | Updated: January 2026
Tricyclic antidepressants: One of a class of medications used to treat depression. The tricyclic antidepressants (TCAs) are also used for some forms of anxiety, fibromyalgia, and the control of chronic pain.
"Tricyclic" refers to the presence of three rings in the chemical structure of these drugs.