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Aygestin Side Effects Center: Detailed Datasheet
Medically reviewed by Min Clinic Staff | Updated: January 2026
- Generic Name: norethindrone
- Brand Name: Aygestin
- Drug Class: Progestins
Aygestin (Norethindrone) side effects drug center
Aygestin Side Effects Center
What Is Aygestin?
Aygestin (norethindrone) is a form of progesterone, a female hormone, used for birth control (contraception) to prevent pregnancy. Aygestin is also used to treat menstrual disorders, endometriosis, or abnormal vaginal bleeding caused by a hormone imbalance. Aygestin is available in generic form.
What Are Side Effects of Aygestin?
Common side effects of Aygestin include:
- nausea,
- Edema
- Changes in weight (decreases, increases)
- Changes in the cervical squamo-columnar junction and cervical secretions
- Cholestatic jaundice
- Rash (allergic) with and without pruritus
- Melasma or chloasma
- Clinical depression
- Acne
- Breast enlargement/tenderness
- Headache/migraine
- Urticaria
- Abnormalities of liver tests (i.e., AST, ALT, Bilirubin)
- Decreased HDL cholesterol and increased LDL/HDL ratio
- Mood swings
- Nausea
- Insomnia
- Anaphylactic/anaphylactoid reactions
- Thrombotic and thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism, retinal vascular thrombosis, cerebral thrombosis and embolism)
- Optic neuritis (which may lead to partial or complete loss of vision)
Read the entire FDA prescribing information for Aygestin (Norethindrone)
© Aygestin Patient Information is supplied by Cerner Multum, Inc. and Aygestin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.