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Activase Side Effects Center

Medically reviewed by Min Clinic Staff | Updated: January 2026
  • Generic Name: alteplase
  • Brand Name: Activase

Activase (Alteplase) side effects drug center

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

 

Activase Side Effects Center

What Is Activase?

Activase (alteplase) is an enzyme, which works to break up and dissolve blood clots that can block arteries, used in the treatment of an acute heart attack or pulmonary embolism.

What Are Side Effects of Activase?

The most common side effect of Activase is bleeding, including gastrointestinal bleeding, genitourinary bleeding, bruising, nosebleed, and bleeding gums. Other side effects of Activase include:

  • nausea,
  • vomiting,
  • low blood pressure (hypotension),
  • dizziness,
  • mild fever, or
  • allergic reactions (swelling, rash, hives).

Activase may cause serious side effects including:

  • severe bleeding (internal or external),
  • bleeding at the injection site,
  • bloody or tarry stools,
  • coughing up blood or vomit that looks like coffee grounds, and
  • sudden numbness or weakness (especially on one side of the body).

Get medical help right away if you have any of the symptoms listed above.

Dosage for Activase

The recommended total dose of Activase is based upon patient weight, not to exceed 100 mg.

What Drugs, Substances, or Supplements Interact with Activase?

Activase may interact with blood thinners or aspirin. Tell your doctor all medications and supplements you use.

Activase During Pregnancy and Breastfeeding

During pregnancy, Activase should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.