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Abitrate: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Abitrate - General Information

Abitrate is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness. Abitrate was first synthesized by Janssen Pharmaceutica in 1955.
It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception.
Abitrate could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.

 

Pharmacology of Abitrate

Abitrate is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Abitrate also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Abitrate through its calcium channel blocking ability also inhibits stimulation of the vestibular system.

 

Additional information about Abitrate

Abitrate Indication

For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.

Mechanism Of Action
Binds to the Histamine H1 receptor and to muscarinic acetylcholine receptors. Abitrate also inhibits contractions of vascular smooth muscle cells by blocking L type calcium channels. Abitrate has also been implicated in binding to dopamine D2 receptors.
Generic Name
Cinnarizine
Drug Category
Anti-Allergic Agents; Calcium Channel Blockers; Histamine H1 Antagonists
Drug Type
Small Molecule; Approved
Other Brand Names containing Cinnarizine
Abitrate; Aplactan; Aplexal; Apotomin; Artate; Carecin; Cerebolan; Cerepar; Cinaperazine; Cinazyn; Cinnacet; Cinnageron; Cinnarizine Stugeron; Corathiem; Denapol; Dimitron; Dimitronal; Eglen; Folcodal; Giganten; Glanil; Hilactan; Ixertol; Katoseran; Labyrin; Lazeta; Marisan; Midronal; Mitronal; Olamin; Processine; Sedatromin; Sepan; Siptazin; Spaderizine; Stugeron; Stutgeron; Stutgin; Toliman;
Chemical IUPAC Name
1-[di(phenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine
Chemical Formula
C26H28N2
Organisms Affected
Humans and other mammals