Wellferon (GlaxoSmithKline): Full Drug Profile

Wellferon (GlaxoSmithKline) - General Information

Purified, natural (n is for natural) glycosylated human interferon alpha proteins 166 residues

Pharmacology of Wellferon (GlaxoSmithKline)

Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.

Additional information about Wellferon (GlaxoSmithKline)

Wellferon (GlaxoSmithKline) Indication

For treatment of venereal or genital warts caused by the Human Papiloma Virus

Mechanism Of Action

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.

Drug Interactions

Aminophylline Interferon increases the effect and toxicity of theophylline

Food Interactions

Avoid alcohol.

Generic Name

Interferon alfa-n1

Synonyms

Interferon alpha-2 precursor; Interferon alpha-A; LeIF A

Drug Category

Antiviral Agents; Immunomodulatory Agents

Drug Type

Biotech; Approved

Other Brand Names containing Interferon alfa-n1

Wellferon (GlaxoSmithKline);

Half Life

1.2 hours (mammalian reticulocytes, in vitro); >20 hours (yeast, in vivo); >10 hours (Escherichia coli, in vivo).

Chemical IUPAC Name

Human interferon alpha

Chemical Formula

C860H1353N227O255S9