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Podomexef: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Podomexef - General Information

Podomexef is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis.

 

Pharmacology of Podomexef

Podomexef is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.

 

Additional information about Podomexef

Podomexef Indication: For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms. Mechanism Of Action: Podomexef is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Podomexef is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Podomexef is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. Drug Interactions: Not Available Food Interactions: Take on empty stomach: 1 hour before or 2 hours after meals. Generic Name: Cefpodoxime Synonyms: Cefpodoxime proxetil; CPDX-PR Drug Category: Cephalosporins; Antibacterial Agents Drug Type: Small Molecule; Approved Other Brand Names containing Cefpodoxime: Vantin; Banan; Doxef; Orelox; Otreon; Podomexef; Absorption: Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically. Toxicity (Overdose): Not Available Protein Binding: 22 to 33% in serum and from 21 to 29% in plasma. Biotransformation: Not Available Half Life: 2.09 to 2.84 hours Dosage Forms of Podomexef: Tablet, film coated OralGranule, for suspension Oral Chemical IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical Formula: C15H17N5O6S2 Cefpodoxime on Wikipedia: https://en.wikipedia.org/wiki/Cefpodoxime Organisms Affected: Enteric bacteria and other eubacteria