Ogostal
Ogostal - General Information
Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. [PubChem]
Pharmacology of Ogostal
Ogostal is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB).
Additional information about Ogostal
Ogostal Indication: Used in the treatment of tuberculosis in combination with other drugs.
Mechanism Of Action: Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Ogostal also binds to components in the bacterial cell which result in the production of abnormal proteins. These proteins are necessary for the bacteria's survival. Therefore the production of these abnormal proteins is ultimately fatal to the bacteria.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Capreomycin
Synonyms: Capreomycin sulphate; Capreomycin; Capastat; Capastat sulfate; Capreomycin sulfate
Drug Category: Anti-Bacterial Agents; Antibiotics, Antitubercular
Drug Type: Small Molecule; Approved
Other Brand Names containing Capreomycin: Ogostal; Caprocin;
Absorption: Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally.
Toxicity (Overdose): Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD50) in mice was 514 mg/kg.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Ogostal: Not Available
Chemical IUPAC Name: (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide; (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide
Chemical Formula: C50H88N28O15
Capreomycin on Wikipedia: https://en.wikipedia.org/wiki/Capreomycin
Organisms Affected: Enteric bacteria and other eubacteria
