Natil: Full Drug Profile

Natil - General Information

A direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. Natil is not approved for use in the U.S. or Canada, but is approved in various European countries.

Pharmacology of Natil

Natil is in a class of drugs called vasodilators. Natil relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily.

Additional information about Natil

Natil Indication

Used in the treatment of various blood vessel diseases (e.g., claudication, arteriosclerosis and Raynaud's disease) and nighttime leg cramps.

Mechanism Of Action

Natil produces peripheral vasodilation by a direct effect on vascular smooth muscle.

Food Interactions

Take with food to reduce irritation.

Generic Name

Cyclandelate

Synonyms

Cyclandelic acid; Ciclandelato [inn-spanish]; Cyclandelatum [inn-latin]; 3,5,5-Trimethylcyclohexyl mandelate; 3,5,5-Trimethylcyclohexyl amygdalate; 3,3,5-Trimethylcyclohexyl mandelate

Drug Category

Vasodilator Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Cyclandelate

Arto-espasmol; Capilan; Ciclospasmol; Clandilon; Cyclergine; Cyclobral; Cyclolyt; Cyclomandol; Cyclospasmol; Dilatan; Natil; Novodil; Perebral; Saiclate; Sancyclan; Sepyron; Spasmione; Spasmocyclon; Spasmocyclone; Vasodyl;

Absorption

Well absorbed following oral administration.

Toxicity (Overdose)

Acute oral toxicity (LD50): 3950 mg/kg [Guinea pig]

Dosage Forms of Natil

Tablet Oral

Chemical IUPAC Name

(3,3,5-trimethylcyclohexyl) 2-hydroxy-2-phenylacetate

Chemical Formula

C17H24O3

Organisms Affected

Humans and other mammals