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Kemadrin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Kemadrin - General Information

A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. [PubChem]

 

Pharmacology of Kemadrin

Kemadrin has an atropine-like action. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.

 

Kemadrin for patients

Patient Information:

Follow your doctors instructions for taking this medicine. This medicine can be taken with food or a snack,
to minimize stomach upset. As your body becomes used to the medicine, it should be taken on an empty
stomach. Talk to your doctor about the best time of day to take the medicine. For patients taking the
extended-release forms, swallow the tablet whole, do NOT CRUSH or CHEW. You may break the tablet in half
if the whole pill is too large for you to take.

This medicine can cause dizziness or drowsiness. Be cautious when driving or performing other hazardous
activities. This medicine can impair judgment. Do NOT increase your dose of this medicine without first
talking to your doctor, even if you feel that the medicine is not working.

Discuss the risks and benefits of using this medicine during pregnancy. It is unknown whether this medicine
is excreted in breast milk. DO NOT breastfeed while taking this medicine until you have talked to your
doctor or pediatrician.

 

Kemadrin Interactions

Drug Interactions:

Procyclidine can interact with the follwing drugs:

amantadine or rimantadine, narcotic analgesics, amitriptyline (Elavil, Endep), doxepin (Sinequan), or
clomipramine (Anafranil), quinidine (Quinora, Quinaglute, Quinidex, Cardioquin), some antiarrhythmics,
antihistamines (diphenhydramine, chlorpheniramine, triprolidine, brompheniramine, clemastine, etc),
Atenolol, Cholinergic agents (tacrine and donepezil), Digoxin, Levodopa, phenothiazines, chlorpromazine
(Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine
(Mellaril), promazine (Sparine), trifluoperazine, and haloperidol.

Drugs other than listed here may also have interactions with Procyclidine.

 

Kemadrin Contraindications

Procyclidin should not be given to patients with angle-closure glaucoma.

 

Additional information about Kemadrin

Kemadrin Indication: For the treatment of Parkinson's Disease (especially drug induced) Mechanism Of Action: The mechanism of action is unknown. It is thought that Kemadrin acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Procyclidine Synonyms: Prociclidina [Inn-Spanish]; Procyclidinum [Inn-Latin] Drug Category: Antiparkinson Agents; Antidyskinetics; Muscarinic Antagonists Drug Type: Small Molecule; Approved Other Brand Names containing Procyclidine: Arpicolin; Elorine; Kemadrin; Kemadrine; Lergine; Metanin; Osnervan; Procyclid; Procyklidin; Prosyklidin; Spamol; Triciclidina; Triciloid; Tricoloid; Tricyclamol; Vagosin; Absorption: Not Available Toxicity (Overdose): LD50=60 mg/kg (IV in mice) Protein Binding: Approximately 100% bound to albumin. Biotransformation: Not Available Half Life: Not Available Dosage Forms of Kemadrin: Tablet OralElixir Oral Chemical IUPAC Name: 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Chemical Formula: C19H29NO Procyclidine on Wikipedia: https://en.wikipedia.org/wiki/Procyclidine Organisms Affected: Humans and other mammals