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Ixel: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Ixel - General Information

Ixel is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. Ixel has been approved and sold in Austria since September 1998 under the brand name Ixel. Cypress Bioscience bought the exclusive rights for approval and marketing of the drug for any purpose in the US and Canada in 2003 from the manufacturer Pierre Fabre; the approval procedure in both countries is ongoing.

 

Pharmacology of Ixel

Not Available

 

Additional information about Ixel

Ixel Indication: Ixel is used to treat moderate to severe clinical depression and chronic pain. Mechanism Of Action: Ixel inhibits norepinephrine and serotonin reuptake in a 3:1 ratio, in practical use this means a balanced (equal) action upon both transmitters. The serotonin reuptake inhibition is likely to improve depression, while the norepinephrine reuptake inihibition probably improves chronic pain. Ixel exerts no significant actions on postynaptic H1, alpha-1, D1, D2, and muscarinic receptors, as well as on benzodiazepine/opiate binding sites. [Wikipedia] Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Milnacipran Synonyms: Milnacipranum [latin]; Midalcipran; (-)-milnacipran; F 2207 Drug Category: Antidepressive Agents; Serotonin Uptake Inhibitors; Adrenergic Uptake Inhibitors Drug Type: Small Molecule; Approved; Investigational Other Brand Names containing Milnacipran: Ixel; Toledomin; Absorption: Milnacipran is well absorbed following oral administration with an absolute bioavailability of 85%. Meals have no effect on absorption. Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Only traces of active metabolites are found. Cytochrome P450 enzymes play no role in the metabolism of Milnacipran. Half Life: 8 hours Dosage Forms of Ixel: Not Available Chemical IUPAC Name: (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide Chemical Formula: C15H22N2O Milnacipran on Wikipedia: https://en.wikipedia.org/wiki/Milnacipran Organisms Affected: Humans and other mammals