Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Hylorel: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Hylorel - General Information

Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter.

 

Pharmacology of Hylorel

High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanadrel works by controlling nerve impulses along certain nerve pathways. As a result, it relaxes the blood vessels so that blood passes through them more easily. This helps to lower blood pressure.

 

Additional information about Hylorel

Hylorel Indication

Used to treat and control hypertension.

Mechanism Of Action
Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter. Guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation. The reduction in neurotransmitter release in response to sympathetic nerve stimulation, as a result of catecholamine depletion, leads to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position.
Generic Name
Guanadrel Sulfate
Synonyms
Guanadrelum [INN-Latin]
Drug Category
Antihypertensive Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Guanadrel Sulfate
Guanadrel; Hylorel;
Absorption
Rapidly and readily absorbed from the gastrointestinal tract.
Toxicity (Overdose)
Side effects include dizziness, drowsiness, headache, constipation, diarrhea, gas pains, loss of appetite, fatigue, and nasal congestion.
Protein Binding
Low, approximately 20%
Biotransformation
Primarily hepatic
Half Life
10 hours
Chemical IUPAC Name
2-(1,4-dioxaspiro[4.5]decan-2-ylmethyl)guanidine
Chemical Formula
C10H19N3O2
Organisms Affected
Humans and other mammals