Dosing and uses of Veregen (sinecatechins topical)
Adult dosage forms and strengths
topical ointment
- 15%
Condylomata Acuminatum
Indicated for topical treatment of external genital and perianal warts (condylomata acuminatum) in immunocompetent patients
Immunocompetent patients: Apply topically tid; use approximately a 0.5-cm strand of ointment for each external genital or perianal wart; continue treatment until complete clearance of all warts, but not to exceed 16 wk
Immunosuppressed patients: Safety and efficacy not established
Pediatric dosage forms and strengths
<18 years: Safety and efficacy not established
Veregen (sinecatechins topical) adverse (side) effects
>10%
Erythema
Pruritus
Burning
Pain/discomfort
Erosion/ulceration
Edema
Induration
Vesicular rash
1-10%
Phimosis
Inguinal lymphadenitis
Desquamation
Discharge
Bleeding
Scarring
Irritation
Rash
Warnings
Contraindications
Hypersensitivity
Cautions
Not evaluated for urethral, intravaginal, cervical, rectal, or intra-anal HPV disease and should not be used to treat these conditions
Avoid application to open wounds, eyes, and nose
Wash hands before and after application
Avoid sexual contact while ointment is on skin
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown whether distributed in breast milk, caution advised
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Veregen (sinecatechins topical)
Mechanism of action
Botanical for topical use consisting of extract from green tea leaves; mode of action unknown, but does elicit antioxidant activity in vitro
