Dosing and uses of Travivo (gepirone)
Major Depressive Disorder
Pending FDA approval for treatment of major depressive disorder
Pharmacology of Travivo (gepirone)
Mechanism of action
Serotonin (5HT)-1a agonist; activation of 5HT-1a leads to glutamate inhibition; without glutamate activation of GABA interneurons, there is no inhibitory control over dopamine release, thereby, increasing dopamine release
