chlorpheniramine/pseudoephedrine (Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever, A.R.M.)
Classes: Antihistamine/Decongestant Combos
- Dosing and uses of Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever (chlorpheniramine/pseudoephedrine)
- Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever (chlorpheniramine/pseudoephedrine) adverse (side) effects
- Warnings
- Pregnancy
- Pharmacology of Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever (chlorpheniramine/pseudoephedrine)
Dosing and uses of Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever (chlorpheniramine/pseudoephedrine)
Adult dosage forms and strengths
chlorpheniramine/pseudoephedrine
liquid
- (2mg/30mg)/5mL
tablet
- 4mg/60mg
Relief of Cold & Flu Symptoms
Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr
Pediatric dosage forms and strengths
chlorpheniramine/pseudoephedrine
liquid
- (2mg/30mg)/5mL
tablet
- 4mg/60mg
Relief of Cold & Flu Symptoms
<6 Years Old
- Ask a pediatrician
6-12 Years Old
- Chlorpheniramine maleate 2 mg and pseudoephedrine HCl 30 mg PO q4-6hr
>12 Years Old
- Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr
Other Indications & Uses
Relief of mild to moderate pain and congestion; Flu symptoms; Common cold
Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever (chlorpheniramine/pseudoephedrine) adverse (side) effects
Frequency not defined
Arrhythmia
Hypotension
Palpitations
Tachycardia
Confusion
Convulsion
Depression
Distress
Dizziness
Drowsiness
Excitability
Euphoria
Fatigue
Headache
Insomnia
Irritability
Sedation
Tremors
Weakness
Anorexia
Agranulocytosis
Hemolytic anemia
Thrombocytopenia
Thickening of bronchial secretions
Wheezing
Warnings
Contraindications
Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer
Cautions
Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine
Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
Pregnancy and lactation
Pregnancy category: C
Lactation: enters breastmilk/contraindicated
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever (chlorpheniramine/pseudoephedrine)
Mechanism of action
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.