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Medically reviewed by Min Clinic Staff | Updated: January 2026
Dosing and uses of Sodium zirconium cyclosilicate
Hyperkalemia
Pending FDA approval for treatment of hyperkalemia
Pharmacology of Sodium zirconium cyclosilicate
Mechanism of action
Insoluble, nonabsorbed zirconium silicate designed to preferentially bind potassium ions by mimicking natural ion channels using a particular sized pore; demonstrated in vitro a >25-fold selectivity for potassium over calcium and magnesium