Dosing and uses of Seromycin (cycloserine)
Adult dosage forms and strengths
capsule
- 250mg
Active Tuberculosis
Initial: 250 mg PO BId
Maintenance: 500 mg -1 g/day in 2 divided doses for 18-24 months; not to exceed 1 g/day
Monitor blood levels
UTI
Initial: 250 mg PO q12hr for first 14 days
Maintenance: 500 mg -1 g/day in divided doses; not to exceed 1 g/day
Monitor blood levels
Gaucher's Disease (Orphan)
Orphan indication sponsor
- Lev, Meir M.D.; The City College, City University Of NY Medical Sc, Convent Avenue at 138 Street; New York, NY 10031
Renal Impairment
CrCl 50-80 mL/min: Give q12-16hr
CrCl 10-49 mL/min: Give q24-36hr
CrCl <10 mL/min: Contraindicated
Administration
Part of multi-drug regimen; not first-line treatment
Pediatric dosage forms and strengths
capsule
- 250mg
Active Tuberculosis
10-20 mg/kg/day PO in divided doses up to 1 g/day for 18-14 months
Renal Impairment
CrCl 50-80 mL/min: Give q12-16hr
CrCl 10-49 mL/min: Give q24-36hr
CrCl <10 mL/min: Contraindicated
Administration
Part of multi-drug regimen; not first-line treatment
Seromycin (cycloserine) adverse (side) effects
Frequency not defined
Confusion
Dizziness
Headache
Somnolence
Seizure
Warnings
Contraindications
Hypersensitivity
Alcohol use
Renal dysfunction, severe
History of seizure disorder, mental depression, severe anxiety or psychosis
Cautions
Alcoholism, anemia, impaired hepatic/renal function
Pregnancy and lactation
Pregnancy category: C
Lactation: enters breast milk; safe
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Seromycin (cycloserine)
Metabolism: liver
Excretion: urine
Mechanism of action
Bacteriostatic or bactericidaL
Inhibits cell wall synthesis
