Dosing and uses of Pin Rid, Pin X (pyrantel pamoate)
Adult dosage forms and strengths
oral suspension
- 250mg/5mL (as base)
capsule
- 180mg (equivalent to 62.5mg base)
chewable tablet
- 720.5mg (equivalent to 250mg base)
Ascariasis (Roundworm)
11 mg (base)/kg PO x1 dose; not to exceed 1 g/dose
Enterobius (Pinworm)
11 mg (base)/kg PO q2week x2 doses; not to exceed 1 g/dose
Eosinophilic Enterocolitis (Hookworm)
11 mg (base)/kg PO qD x3 d; not to exceed 1 g/dose
Administration
May take with food
Pediatric dosage forms and strengths
oral suspension
- 250mg/5mL (as base)
capsule
- 180mg (equivalent to 62.5mg base)
chewable tablet
- 720.5mg (equivalent to 250mg base)
Ascariasis (Roundworm)
<2 years: Safety and efficacy not established
2 years or older: 11 mg (base)/kg PO x1 dose; not to exceed 1 g/dose
Enterobius (Pinworm)
<2 years: Safety and efficacy not established
2 years or older: 11 mg (base)/kg PO q2week x2 doses; not to exceed 1 g/dose
Eosinophilic Enterocolitis (Hookworm)
<2 years: Safety and efficacy not established
2 years or older: 11 mg (base)/kg PO qD x3 d; not to exceed 1 g/dose
Administration
May take with food
Pin Rid, Pin X (pyrantel pamoate) adverse (side) effects
Frequency not defined
Dizziness
Drowsiness
Insomnia
Headache
Rash
Anorexia
Nausea
Vomiting
Abdominal cramps
Diarrhea
Tenesmus
Elevated LFTs
Weakness
Warnings
Contraindications
Hypersensitivity
Intestinal obstruction
Hepatic disease
Cautions
Anemia, hepatic impairment, malnutrition
Pregnancy and lactation
Pregnancy category: C
Lactation: unknown
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Pin Rid, Pin X (pyrantel pamoate)
Absorption: poor
Metabolism: partially hepatic
Peak Plasma Time: 1-3 hr
Excretion
Feces: 50% (as unchanged drug)
Urine: 7% (as unchanged drug)
Mechanism of action
Depolarizing neuromuscular blocker, inhibits cholinesterases, causing spastic paralysis
