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arbaclofen (Ontinua ER): Dosing and Uses

 

Classes: Skeletal Muscle Relaxants

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dosing and uses of Ontinua ER (arbaclofen)

 

Spasticity

Pending FDA approval for treatment of spasticity in patients with multiple sclerosis (MS)

 

Pharmacology of Ontinua ER (arbaclofen)

Mechanism of action

Prodrug that is converted R-enantiomer of baclofen; allows for oral dosing with higher bioavailability

Inhibits synaptic transmission through spinal reflex arcs via hyperpolarization of primary afferent fiber terminals; this inhibition may decrease in muscle spasticity