Dosing and uses of Lotrisone (clotrimazole/betamethasone)
Adult dosage forms and strengths
clotrimazole/betamethasone
cream/lotion
- 0.05%/1%
Tinea Pedis, Tinea Cruris, & Tinea Corporis
Apply to infected area q12hr for 2 weeks for tinea cruris and tinea corporis; 4 weeks for tinea pedis
Allergic or Inflammatory Diseases
Apply to affected area in the morning and evening
Pediatric dosage forms and strengths
<17 years: Safety and efficacy not established
Lotrisone (clotrimazole/betamethasone) adverse (side) effects
1-10%
Dry skin (2%)
Paresthesia (2%)
Local burning (2%)
<1%
Edema
Rash
Skin atrophy
Secondary infection
Skin ulceration
Acneiform eruption
Bruising
Folliculitis
Striae
Clotrimazole
Erythema
Stinging
Blistering
Peeling
Edema
Pruritus
Urticaria
General skin irritation
Betamethasone
Burning
Itching
Irritation
Dryness
Folliculitis
Hypertrichosis
Acneiform eruptions
Hypopigmentation
Perioral dermatitis
Allergic contact dermatitis
Skin maceration
Skin atrophy
Striae
Miliaria
HPA suppression (with higher potency used >2 wk)
Warnings
Contraindications
Documented hypersensitivity
Cautions
Do not use with occlusive dressing; systemic absorptioin of topical corticosteroids may cause hypercorticism or suppression of hypothalamic-pituitary-adrenal axis
Prolonged treatment with corticosteroids associated with development of Kaposi sarcoma
Topical corticosteroids may be absorbed percutaneously and result in manifestations of Cushing syndrome
Pregnancy and lactation
Pregnancy category: C
Lactation: Excretion in milk unknown; use with caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Lotrisone (clotrimazole/betamethasone)
Mechanism of action
Betamethasone: Decreases inflammation by stabilizing leukocyte lysosomal membranes
Clotrimazole: Binds to phospholipids in fungal cell membrane, which alters cell wall permeability and results in the loss of intracellular elements; fungistatic and fungicidaL
