Dosing and uses of Granulex, Xenaderm (castor-oil-trypsin)
Adult dosage forms and strengths
castor oil / trypsin
ointment
- (60g)
spray
- (113.4g)
- (340.2g)
Treatment of Skin Ulcers & Wound Healing
Ointment: Apply thin film BID or more often PRn
Spray: Apply BID or more often PRn
Administration
May be left undressed or bandaged with appropriate dressing
Other Indications & Uses
Debridement of eschar
Pediatric dosage forms and strengths
Safety & efficacy not established
Granulex, Xenaderm (castor-oil-trypsin) adverse (side) effects
Frequency not defined
Transient "burning" sensation upon application
Skin irritation
Warnings
Contraindications
Hypersensitivity
Cautions
Do not use on fresh arterial clots
Avoid spraying on eyes
Spray is flammable
Pregnancy and lactation
Pregnancy category: N/A
Lactation: N/A
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Granulex, Xenaderm (castor-oil-trypsin)
Metabolism: N/A
Excretion: N/A
Mechanism of action
Trypsin digests proteins in necrotic tissue
Balsam stimulates capillary bed & improves circulation in the wound area
Castor oil promotes reepithelialization
