folic acid/cyanocobalamin/pyridoxine (Foltx, folic acid/vitamin B12/vitamin B6, Folbic)

Dosing and uses of Foltx, folic acid/vitamin B12/vitamin B6 (folic-acid-cyanocobalamin-pyridoxine)

• Adult
• Pediatric

 

Adult dosage forms and strengths

folic acid/cyanocobalamin/pyridoxine

tablet

• 0.4mg/250mg/25mg
• 0.8mg/100mcg/50mg
• 0.8mg/1000mcg/50mg
• 0.8mg/115mcg/10mg
• 0.8mg/250mcg/25mg
• 0.8mg/400mcg/25mg
• 2.2mg/500mcg/25mg
• 2.2mg/1000mcg/25mg
• 2.2mg/1300mcg/25mg
• 2.5mg/2000mcg/25mg
• 2.5mg/1000mcg/25mg

 

Daily Dietary Supplement

1 tab PO qDay

 

Pediatric dosage forms and strengths

Safety & efficacy not established

 

Foltx, folic acid/vitamin B12/vitamin B6 (folic-acid-cyanocobalamin-pyridoxine) adverse (side) effects

Frequency not defined

Allergic reactions

Bronchospasm

Flushing

Malaise

Erythema

Rash

Paresthesias

Somnolence

Unsteady gait

Diarrhea

Nausea

Pruritus

Urticaria

Altered sleep patterns

Irritability

Peripheral vascular thrombosis

Polycythemia

 

Warnings

Contraindications

Hypersensitivity to any component

 

Pregnancy and lactation

Pregnancy category: See individual agents

Lactation: Safe

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Nutrition

See individual monographs

 

Pharmacology of Foltx, folic acid/vitamin B12/vitamin B6 (folic-acid-cyanocobalamin-pyridoxine)

Mechanism of action

Folic acid: Plays a role in the formation of coenzymes involved in purine and pyrimidine synthesis as well as other metabolic systems; required for nucleoprotein synthesis and maintenance of erythropoiesis; enhances metabolism of formic acid, the toxic metabolite of methanol, to nontoxic metabolites

Cyanocobalamin: Plays a role in cell replication and hematopoiesis; coenzyme in protein synthesis as well as fat and carbohydrate metabolism

Pyridoxine: Plays a role in carbohydrate, protein, and fat metabolism; aids in the release of liver and muscle stored glycogen and the synthesis of GABA