Dosing and uses of Flavoxate
Adult dosage forms and strengths
tablets
- 100 mg
Overactive Bladder
Indicated for dysuria, increased urinary frequency/incontinence, nocturia, suprapubic pain, urinary incontinence, urinary tract irritation, urinary urgency
100-200 mg PO q6-8hr
Pediatric dosage forms and strengths
tablets
- 100 mg
Dysuria, Urinary Frequency
Indicated for dysuria, increased urinary frequency, nocturia, suprapubic pain, urinary incontinence, urinary tract irritation, urinary urgency
<12 years: Not recommended; safety and efficacy not established
≥12 years: 100-200 mg PO q6-8hr
Flavoxate adverse (side) effects
Frequency not defined
Abdominal pain
Blurred vision
Confusion
Constipation
Disturbance in ocular accommodation
Drowsiness
Dry mouth/throat
Dysuria
Eosinophilia
Headache
Hyperpyrexia
Increased ocular tension
Nausea
Nervousness
Palpitation
Tachycardia
Urticaria
Vertigo
Vomiting
Warnings
Contraindications
Obstructive uropathy, pyloric/duodenal obstruction, ileus, GI bleeding, achalasia
Cautions
Use with caution in patients with glaucoma
May impair ability to perform hazardous tasks
May cause ocular disturbances; advice patients of potential effects
Vertigo may occur
Pregnancy and lactation
Pregnancy category: B
Lactation: not known if excreted in breast milk, use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Flavoxate
Mechanism of action
Anticholinergic smooth muscle relaxant that inhibits phosphodiesterase and counteracts muscle spasm in urinary tract; also relaxes detrusor muscle
Pharmacokinetics
Onset: 55 min
Peak Effect: 112 min
Excretion: Urine (10-30%)
