Dosing and uses of Firdapse (amifampridine phosphate)
Lambert-Eaton Myasthenic Syndrome (LEMS)
Pending FDA approval for symptomatic treatment of LEMS in adults
Myasthenia Gravis (Orphan)
Orphan designation for treatment of myasthenia gravis
Sponsor
- Catalyst Pharmaceuticals, Inc; 355 Alhambra Circle Suite 1250; Coral Gables, Florida 33134
Pediatric dosage forms and strengths
Congenital Myasthenic Syndromes (Orphan)
Orphan designation for treatment of congenital myasthenic syndromes
Sponsor
- Catalyst Pharmaceuticals, Inc; Suite 1500; Coral Gables, Florida 33134
Pharmacology of Firdapse (amifampridine phosphate)
Mechanism of action
Blocks voltage-dependent potassium channels, thereby prolonging presynaptic cell membrane depolarization which enhances calcium transport into nerve-endings
The increased intracellular calcium concentrations facilitate exocytosis of acetylcholine-containing vesicles, which in turn enhances neuromuscular transmission
