Dosing and uses of Butisol (butabarbital)
Adult dosage forms and strengths
elixir: Schedule III
- 30mg/5mL
tablet: Schedule III
- 30mg
- 50mg
Sedative or Hypnotic
Hypnotic: 50-100 mg qHs
Daytime sedation: 15-30 mg q6-8hr
Preoperative sedation: 50-100 mg 60-90 minutes before surgery
Renal Impairment
Reduce dosage if use is necessary
Hepatic Impairment
Reduce dosage if use is necessary
Pediatric dosage forms and strengths
elixir: Schedule III
- 30mg/5mL
tablet: Schedule III
- 30mg
- 50mg
Sedation
Preoperative sedation: 2-6 mg/kg; not to exceed 100 mg/dose
Geriatric dosage forms and strengths
Use with caution; may administer a dose at the low end of the range
Butisol (butabarbital) adverse (side) effects
1-10%
Somnolence
<1%
Abnormal thinking
Agitation
Anxiety
Apnea
Ataxia
Bradycardia
CNS depression
Confusion
Constipation
Dizziness
Fever
Hallucination
Headache
Hepatotoxicity
Hypersensitivity rxn
Hypoventilation
Insomnia
Nausea
Nervousness
Nightmares
Psychiatric disturbance
Vomiting
Warnings
Contraindications
Barbiturate or tartrazine sensitivity, liver disease, severe respiratory disease, porphyria
Cautions
May impair mental and physical abilities by depressing the central nervous system
May cause hyperactivity and agitation
Use caution in patients with depression, renal or hepatic impairment, or respiratory disease
Pregnancy and lactation
Pregnancy category: d
Lactation: Enters breast milk; use with caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Butisol (butabarbital)
Mechanism of action
Interferes with transmission of impulses from the thalamus to the cortex; depresses sensory cortex & decreases motor activity
Pharmacokinetics
Half-Life: ~100 hr
Duration: 6-8 hr
Onset: 45-60 min
Enzymes induced: CYP1A2, CYP2C9/10, CYP3A4
Excretion: Urine
