Dosing and uses of Arestin (minocycline dental)
Adult dosage forms and strengths
cartridge
- 1mg
Periodontitis
Varies depending on size, shape, & number of pockets
Up to 121 1-mg cartridges have been used in a single visit
Administration
Does not require local anesthesia
Insert unit-dose cartridge to the base of the periodontal pocket & press thumb ring in the handle mechanism to expel powder while gradually withdrawing the tip from pocket base
Handle mechanism should be sterilized between patients
Does not have to be removed (bioresorbable), nor is an adhesive or dressing required
Other Indications & Uses
Adjunct during dental scaling & root planing to reduce pocket depth in adults with periodontitis
Pediatric dosage forms and strengths
Safety & efficacy not established
Arestin (minocycline dental) adverse (side) effects
Mostly comparable to control; only those markedly higher are listed
1-10%
Dyspepsia
Mouth ulceration
Mucous membrane disorder
Pharyngitis
Warnings
Contraindications
Hypersensitivity to minocycline or tetracyclines
Acutely abscessed periodontal pockets
Cautions
May cause tooth discoloration in utero
Pregnancy and lactation
Pregnancy category: d
Lactation: tetracyclines excreted in milk, discontinue drug or do not nurse
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Arestin (minocycline dental)
Distribution: saliva >>serum
Mechanism of action
Antibiotic of the tetracycline class
