lidocaine/hydrocortisone (AnaMantle, Ana-Lex)
Classes: Anesthetics/Corticosteroid Combos; Anesthetics, Topical; Corticosteroids, Topical
Dosing and uses of AnaMantle, Ana-Lex (lidocaine/hydrocortisone)
Adult dosage forms and strengths
lidocaine/hydrocortisone
topical pads
- 2%/2%
rectal geL
- 2%/2.5%
rectal cream
- 2%/2%
Skin Disorders
Apply q8-12hr
Hemorrhoids, Anal fissures, Pruritus ani
Apply BID to areas of discomfort and anal opening
Pediatric dosage forms and strengths
Safety and efficacy not established
AnaMantle, Ana-Lex (lidocaine/hydrocortisone) adverse (side) effects
Frequency not defined
Adrenal suppression
Anaphylaxis
Angioedema
Blanching
Cushing syndrome
Stinging
Hirsutism
Acne
Cutaneous and subcutaneous atrophy
Dry scaly skin
Echymoses and petechia
Hyperpigmentation
Hypopigmentation
Edema
Urticaria
Impaired wound healing
Rash
Warnings
Contraindications
Hypersensitivity
Cautions
Systemic absorption of topical corticosteroids may cause hypothalamic-pituitary axis suppression when applied over large surface areas; other adverse effects include hyperglycemia, HPA suppression, glycosuria, fluid and electrolyte changes, hyperglycemia etc
Allergic contact dermatitis
Prolonged treatment with corticosteroids is associated with development of Kaposi’s sarcoma
Discontinue if infection develops.
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown if distributed in breast milk; exercise caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of AnaMantle, Ana-Lex (lidocaine/hydrocortisone)
Mechanism of action
Combination therapy; anti-inflammatory, antipruritic, and vasoconstrictive effects
Absorption
Rectal absorption: 26%
Administration
Instructions
Insert applicator gently into anal area when administering
For external use only; avoid contact with eyes, nose, or ears
