Vyepti vs. Botox

Vyepti (eptinezumab-jjmr) and Botox (onabotulinumtoxinA) are used to treat and prevent migraine in adults.

Botox is also used to treat limb spasticity, axillary hyperhidrosis, cervical dystonia, strabismus, and blepharospasm.

Vyepti and Botox belong to different drug classes. Vyepti is a calcitonin gene-related peptide antagonist and Botox is an injectable neuro-toxin.

Side effects of Vyepti and Botox that are similar include runny or stuffy nose.

Side effects of Vyepti that are different from Botox include hypersensitivity reactions (itching, flushing).

Side effects of that are different from Vyepti include allergic reactions, rash, itching, headache, neck or back pain, muscle stiffness, difficulty swallowing, shortness of breath, nausea, diarrhea, stomach pain, loss of appetite, muscle weakness, injection site reactions (bruising, bleeding, pain, redness, swelling, or infection), fever, cough, sore throat, flu symptoms, cold symptoms, respiratory infections, dizziness, drowsiness, tired feeling, anxiety, dry mouth, ringing in the ears, increased sweating in areas other than the underarms, urinary tract infections (UTIs), burning/painful urination, and difficulty urinating.

Vyepti may interact with other drugs.

Botox may interact with other agents (for example, aminoglycosides, curare) that affect neuromuscular function.

Side effects of Vyepti include:

• runny or stuffy nose and
• hypersensitivity reactions (itching, flushing)

Common side effects of Botox include:

• allergic reactions,
• rash,
• itching,
• headache,
• neck or back pain,
• muscle stiffness,
• difficulty swallowing,
• shortness of breath,
• nausea,
• diarrhea,
• stomach pain,
• loss of appetite,
• muscle weakness,
• injection site reactions including
  • bruising,
  • bleeding,
  • pain,
  • redness,
  • swelling, or
  • infection,
• fever,
• cough,
• sore throat,
• runny nose,
• flu symptoms,
• cold symptoms
• respiratory infections,
• dizziness,
• drowsiness,
• tired feeling,
• anxiety,
• dry mouth,
• ringing in your ears,
• increased sweating in areas other than the underarms,
• urinary tract infections,
• burning/painful urination, and
• difficulty urinating

Drooping of the eyelid (ptosis), inflammation of the cornea (keratitis), eye dryness, itchy eyes, double vision, eye irritation, tearing, increased sensitivity to light, reduced blinking, and eyelid swelling or bruising may occur when used for treating blepharospasm.

Vyepti (eptinezumab-jjmr) is a calcitonin gene-related peptide antagonist indicated for the preventive treatment of migraine in adults.

Botox (onabotulinumtoxinA) is an injectable neuro-toxin used for the treatment of chronic migraines, limb spasticity, axillary hyperhidrosis, cervical dystonia, strabismus, and blepharospasm.

Vyepti may interact with other medicines.

Tell your doctor all medications and supplements you use.

Administration of botulinum toxin with other agents (for example, aminoglycosides, curare) that affect neuromuscular function may increase the effect of botulinum toxin.

The recommended dosage of Vyepti is 100 mg as an intravenous infusion over approximately 30 minutes every 3 months. Some patients may benefit from a dosage of 300 mg.

Botox is administered by injection and dosing depends on the condition that it is used for.