Tresiba vs. Toujeo
Are Tresiba and Toujeo the Same Thing?
Tresiba (insulin degludec injection) and Toujeo (insulin glargine) are long-acting human insulin analogs used to improve glycemic control in patients with diabetes mellitus.
Side effects of Tresiba and Toujeo that are similar include low blood sugar (hypoglycemia), allergic reactions, injection site reactions, body fat redistribution, itching, rash, swelling, weight gain, cold symptoms such as runny or stuffy nose, and upper respiratory tract infection.
Side effects of Tresiba that are different from Toujeo include headache, sinusitis, upset stomach or stomach pain, and diarrhea.
Both Tresiba and Toujeo may interact with other insulin products, beta-blockers, clonidine, guanethidine, reserpine, other antidiabetic agents, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors (MAOIs), pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, and lithium salts.
Tresiba may also interact with GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, and pentamidine.
Toujeo may also interact with clonidine.
What Are Possible Side Effects of Tresiba?
Side effects of Tresiba include:
- low blood sugar (hypoglycemia),
- allergic reactions,
- injection site reactions,
- body fat redistribution (lipodystrophy),
- itching,
- rash,
- swelling,
- weight gain,
- runny or stuffy nose,
- upper respiratory tract infection,
- headache,
- sinusitis,
- upset stomach or stomach pain, and
- diarrhea.
What Are Possible Side Effects of Toujeo?
Common side effects of Toujeo include:
- cold symptoms
- upper respiratory tract infection
- low blood sugar (hypoglycemia)
- allergic reactions
- injection site reactions
- body fat redistribution (lipodystrophy)
- itching
- rash
- swelling of extremities, and
- weight gain
What Is Tresiba?
Tresiba (insulin degludec injection) is a long-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.
What Is Toujeo?
Toujeo (insulin glargine) Injection is along-acting insulin indicated to improve glycemic control in adults with diabetes mellitus.
What Drugs Interact With Tresiba?
Tresiba may interact with other insulin products, beta-blockers, clonidine, guanethidine, reserpine, other antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, lithium salts, or pentamidine. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while taking Tresiba. During pregnancy, Tresiba should only be taken if prescribed. It is unknown if Tresiba passes into breast milk. Women with diabetes who are nursing may require adjustments in insulin dose, meal plan, or both. Consult your doctor before breastfeeding.
What Drugs Interact With Toujeo?
Toujeo may interact with other antidiabetic drugs, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blocking agents (ARBs), disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors (MAOIs), pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isonazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic drugs, thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, clonidine, guanethidine, and reserpine. Tell your doctor all medications and supplements you use.
How Should Tresiba be Taken?
The dose of Tresiba is individualized based on type of diabetes, metabolic needs, blood glucose monitoring results, and glycemic control goal.
How Should Toujeo be Taken?
The recommended starting dose of Toujeo in insulin naïve patients with type 1 diabetes is approximately one-third to one-half of the total daily insulin dose. The remainder of the total daily insulin dose should be given as a short-acting insulin and divided between each daily meal. As a general rule, 0.2 to 0.4 units of insulin per kilogram of body weight can be used to calculate the initial total daily insulin dose in insulin naïve patients with type 1 diabetes. The recommended starting dose of Toujeo in insulin naïve patients with type 2 diabetes is 0.2 units per kilogram of body weight once daily.
