Tresiba vs. Basaglar

Tresiba (insulin degludec injection) and Basaglar (insulin glargine injection) are long-acting human insulin analogs used to improve glycemic control in patients with diabetes mellitus.

Side effects of Tresiba and Basaglar that are similar include low blood sugar (hypoglycemia), allergic reactions, injection site reactions, body fat redistribution, itching, rash, swelling, weight gain, upper respiratory tract infection, runny or stuffy nose, headache, and diarrhea.

Side effects of Tresiba that are different from Basaglar include sinusitis and upset stomach or stomach pain.

Side effects of Basaglar that are different from Tresiba include back pain, cough, urinary tract infection (UTI), and depression.

Both Tresiba and Basaglar may interact with other insulin products, beta-blockers, clonidine, guanethidine, reserpine, other antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, and lithium salts.

Tresiba may also interact with GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics, and pentamidine.

Common side effects of Tresiba include:

• low blood sugar (hypoglycemia),
• allergic reactions,
• injection site reactions,
• body fat redistribution (lipodystrophy),
• itching,
• rash,
• swelling,
• weight gain,
• runny or stuffy nose,
• upper respiratory tract infection,
• headache,
• sinusitis,
• upset stomach or stomach pain, and
• diarrhea.

Common side effects of Basaglar include:

• low blood sugar (hypoglycemia),
• allergic reactions,
• injection site reactions,
• body fat redistribution,
• itching,
• rash,
• swelling,
• weight gain,
• upper respiratory tract infection,
• runny or stuffy nose,
• back pain,
• cough,
• urinary tract infection,
• diarrhea,
• depression, or
• headache.

Tresiba (insulin degludec injection) is a long-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.

Basaglar (insulin glargine injection) is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.

Tresiba may interact with other insulin products, beta-blockers, clonidine, guanethidine, reserpine, other antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, lithium salts, or pentamidine. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while taking Tresiba. During pregnancy, Tresiba should only be taken if prescribed. It is unknown if Tresiba passes into breast milk. Women with diabetes who are nursing may require adjustments in insulin dose, meal plan, or both. Consult your doctor before breastfeeding.

Basaglar may interact with antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, guanethidine, and reserpine. Tell your doctor all medications and supplements you use.

The dose of Tresiba is individualized based on type of diabetes, metabolic needs, blood glucose monitoring results, and glycemic control goal.

The dose of Basaglar is individualized based on metabolic needs, blood glucose monitoring, glycemic control, type of diabetes, and prior insulin use.