Plegridy vs. Ocrevus
Are Plegridy and Ocrevus the Same Thing?
Plegridy (peginterferon beta-1a) Autoinjector and Ocrevus (ocrelizumab) injection are used to treat patients with relapsing forms of multiple sclerosis.
Ocrevus is also used to treat primary progressive forms of multiple sclerosis.
Plegridy is an interferon beta-1a and Ocrevus is a CD20-directed cytolytic antibody.
Side effects of Plegridy that are different from Ocrevus include injection site reactions (redness, itching, pain, swelling, warmth, rash, bruising), flu-like illness, fever, headache, muscle or joint pain, chills, weakness, nausea, and vomiting.
Side effects of Ocrevus that are different from Plegridy include upper respiratory tract infections, infusion reactions (itching, rash, hives, redness, bronchospasm, swollen and sore throat, mouth pain, shortness of breath, flushing, hypotension, fever, fatigue, headache, dizziness, nausea, and fast heart rate), skin infections, lower respiratory tract infections, depression, back pain, and pain in the extremities.
Plegridy may interact with other drugs.
Ocrevus may interact with other immune-modulating or immunosuppressive therapies, including immunosuppressant doses of corticosteroids.
What Are Possible Side Effects of Plegridy?
Common side effects of Plegridy include:
- injection site reactions (redness, itching, pain, swelling, warmth, rash, bruising),
- flu-like illness,
- fever,
- headache,
- muscle or joint pain,
- chills,
- weakness,
- nausea, and
- vomiting
What Are Possible Side Effects of Ocrevus?
Common side effects of Ocrevus include:
- upper respiratory tract infections,
- infusion reactions (itching, rash, hives, redness, bronchospasm, swollen and sore throat, mouth pain, shortness of breath, flushing, hypotension, fever, fatigue, headache, dizziness, nausea, and fast heart rate),
- skin infections,
- lower respiratory tract infections,
- depression,
- back pain, and
- pain in the extremities.
What Is Plegridy?
Plegridy (peginterferon beta-1a) Autoinjector is an interferon beta-1a used to treat patients with relapsing forms of multiple sclerosis.
What Is Ocrevus?
Ocrevus (ocrelizumab) injection is aCD20-directed cytolytic antibody indicated for the treatment of patients with relapsing or primary progressive forms of multiple sclerosis.
What Drugs Interact With Plegridy?
Tell your doctor all medications and supplements you use. During pregnancy, Plegridy should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
What Drugs Interact With Ocrevus?
Hepatitis B virus screening is required before the first dose of Ocrevus. Pre-medicate with methylprednisolone (or an equivalent corticosteroid) and an antihistamine prior to each infusion. The starting dose of Ocrevus is 300 mg intravenous infusion, followed two weeks later by a second 300 mg intravenous infusion. Subsequent doses of Ocrevus are 600 mg intravenous infusion every 6 months.
How Should Plegridy Be Taken?
The recommended dosage of Plegridy is 125 micrograms injected subcutaneously every 14 days.
How Should Ocrevus be Taken?
Hepatitis B virus screening is required before the first dose of Ocrevus. Pre-medicate with methylprednisolone (or an equivalent corticosteroid) and an antihistamine prior to each infusion. The starting dose of Ocrevus is 300 mg intravenous infusion, followed two weeks later by a second 300 mg intravenous infusion. Subsequent doses of Ocrevus are 600 mg intravenous infusion every 6 months.