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Maxalt vs. Treximet

Are Maxalt and Treximet the Same Thing?

Maxalt (rizatriptan) and Treximet (sumatriptan and naproxen sodium) contain selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonists (“triptans”) and are used to treat the pain of migraine headache. Maxalt and Treximet will only treat a headache that has already begun. They will not prevent headaches or reduce the number of attacks.

Treximet also contains a nonsteroidal anti-inflammatory drug (NSAID).

Side effects of Maxalt and Treximet that are similar include dry mouth, nausea, pressure or heavy feeling in any part of your body, dizziness, drowsiness, tired feeling, weakness, feelings of tingling/numbness/prickling/heat, or flushing (warmth, redness, or tingling feeling under your skin).

Side effects of Maxalt that are different from Treximet include mild headache (not a migraine) or feeling of pain or tightness in the jaw, neck, or throat.

Side effects of Treximet that are different from Maxalt include heartburn, constipation, upset stomach, or tight muscles.

Both Maxalt and Treximet may interact with antidepressants.

Maxalt may also interact with other migraine headache medicines, propranolol, medicines to treat psychiatric disorders, narcotics, or medicines to prevent nausea and vomiting.

Treximet may also interact with blood thinners, lithium, methotrexate, probenecid, diuretics (water pills), steroids, aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), heart or blood pressure medications, antidepressants, or cold/allergy or pain medications that contain naproxen.

What Are Possible Side Effects of Maxalt?

Common side effects of Maxalt include:

  • mild headache (not a migraine),
  • dry mouth,
  • nausea;
  • feeling of pain or tightness in the jaw, neck, or throat;
  • pressure or heavy feeling in any part of your body,
  • dizziness,
  • drowsiness,
  • tired feeling,
  • weakness,
  • feelings of tingling/numbness/prickling/heat, or
  • flushing (warmth, redness, or tingling feeling under your skin).

What Are Possible Side Effects of Treximet?

Common side effects of Treximet include:

  • dizziness
  • drowsiness
  • flushing (warmth, heat, or tingly feeling)
  • redness in your face
  • feelings of prickling/heat
  • tiredness
  • nausea
  • heartburn
  • constipation
  • upset stomach
  • dry mouth
  • tight muscles
  • weakness
  • mild pressure or heavy feeling in any part of your body

What Is Maxalt?

Maxalt (rizatriptan) tablets is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist used to treat the pain of migraine headache. Maxalt is believed to work by narrowing the blood vessels around the brain and by decreasing levels of substances involved in the development of migraine pain. Maxalt will only treat a headache that has already begun. Maxalt will not prevent headaches or reduce the number of attacks.

What Is Treximet?

Treximet (sumatriptan and naproxen sodium) is a combination of a headache medicine and a nonsteroidal anti-inflammatory drug (NSAID) used to treat migraine headaches. Treximet will only treat a headache that has already begun.

What Drugs Interact With Maxalt?

Maxalt may interact with other migraine headache medicines, propranolol, or antidepressants. Tell your doctor all medications and supplements you use. It is not known whether this medication is harmful to an unborn baby. Before taking rizatriptan, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is also not known whether rizatriptan passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

What Drugs Interact With Treximet?

Treximet may interact with blood thinners, lithium, methotrexate, probenecid, diuretics (water pills), steroids, aspirin, other NSAIDs (nonsteroidal anti-inflammatory drugs), ACE inhibitors, beta-blockers, or antidepressants.

How Should Maxalt Be Taken?

The adult dose of Treximet is 1 mg or 2.5 mg tablets taken with fluid. The dose may be repeated once after 4 hours, for a maximum dose of 5 mg in a 24-hour period.

How Should Treximet Be Taken?

Treximet is a tablet with a fixed dose combination of 85 mg sumatriptan and 500 mg naproxen sodium. The usual dose is one tablet.

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