Lyumjev vs. Humalog

Lyumjev (insulin lispro-aabc) and Humalog (insulin lispro [rDNA origin]) Injection are rapid-acting human insulin analogs used to improve glycemic control in adults with diabetes mellitus.

Side effects of Lyumjev and Humalog that are similar include injection site reactions (pain, rash, redness, inflammation, bruising, or itching) and low blood sugar (hypoglycemia) (symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusions, or seizure).

Side effects of Lyumjev that are different from Humalog include allergic reactions, rash, itching, changes in body fat distribution (lipodystrophy), runny or stuffy nose, upper respiratory tract infection, and weight gain.

Side effects of Humalog that are different from Lyumjev include low blood potassium levels (hypokalemia). Symptoms include dry mouth, increased thirst, increased urination, uneven heartbeats, muscle pain or weakness, leg pain or discomfort, or confusion.

Both Lyumjev and Humalog may interact with clonidine, lithium salts, guanethidine, reserpine, and beta-blockers.

Lyumjev may also interact with antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents (ARBs), disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors (MAOIs), pentoxifylline, pramlintide, salicylates, somatostatin analogs, sulfonamide antibiotics, atypical antipsychotics, corticosteroids, danazol, diuretics (water pills), estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, beta-blockers, and lithium salts.

Humalog may also interact with albuterol.

Side effects of Lyumjev include:

• low blood sugar (hypoglycemia),
• injection site reactions (rash, redness, inflammation, bruising, or itching),
• allergic reactions,
• rash,
• itching,
• changes in body fat distribution (lipodystrophy),
• runny or stuffy nose,
• upper respiratory tract infection, and
• weight gain

Common side effects of Humalog include:

• injection site reactions (e.g., pain, redness, irritation).
• Low blood sugar (hypoglycemia), is the most common side effect of insulin lispro such as Humalog.
• Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusions, or seizure (convulsions).
• Low blood potassium levels (hypokalemia). Symptoms include dry mouth, increased thirst, increased urination, uneven heartbeats, muscle pain or weakness, leg pain or discomfort, or confusion

Lyumjev (insulin lispro-aabc) is a rapid-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.

Humalog (insulin lispro [rDNA origin]) Injection is a hormone that is produced in the body used to treat type 1 (insulin-dependent) diabetes in adults. Humalog is usually given together with another long-acting insulin. Humalog is also used together with oral medications to treat type 2 (non insulin-dependent) diabetes in adults.

Lyumjev may interact with other medicines such as:

• antidiabetic agents,
• ACE inhibitors,
• angiotensin II receptor blocking agents (ARBs),
• disopyramide,
• fibrates,
• fluoxetine,
• monoamine oxidase inhibitors (MAOIs),
• pentoxifylline,
• pramlintide,
• salicylates,
• somatostatin analogs (e.g., octreotide),
• sulfonamide antibiotics,
• atypical antipsychotics (e.g., olanzapine and clozapine),
• corticosteroids,
• danazol,
• diuretics (water pills),
• estrogens,
• glucagon,
• isoniazid,
• niacin,
• oral contraceptives,
• phenothiazines,
• progestogens (e.g., in oral contraceptives),
• protease inhibitors,
• somatropin,
• sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline),
• thyroid hormones,
• alcohol,
• beta-blockers,
• clonidine,
• lithium salts,
• guanethidine, and
• reserpine

Tell your doctor all medications and supplements you use.

Humalog may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Many other medicines can increase or decrease the effects of insulin lispro on lowering blood sugar. Tell your doctor all prescription and over-the-counter medications and supplements you use.

The dosage of Lyumjev is based on the patient’s metabolic needs, glucose monitoring results, and glycemic control goal.

The total daily insulin requirement varies and the dose is usually between 0.5 to 1 unit/kg/day. Insulin needs may be altered during stress, major illness, or changes in exercise, meal patterns, or co-administered drugs.