Navigation

Ibsrela vs. Linzess

Are Ibsrela and Linzess the Same Thing?

Ibsrela (tenapanor) and Linzess (linaclotide) are used to treat irritable bowel syndrome with constipation (IBS-C) in adults.

Linzess is also used to treat chronic idiopathic constipation (CIC) in adults.

Ibsrela and Linzess belong to different drug classes. Ibsrela is a sodium/hydrogen exchanger 3 (NHE3) inhibitor and Linzess is a guanylate cyclase-C agonist.

Side effects of Ibsrela and Linzess that are similar include diarrhea, abdominal distension/bloating, and gas (flatulence).

Side effects of Ibsrela that are different from Linzess include dizziness.

Side effects of Linzess that are different from Ibsrela include stomach/abdominal pain or discomfort, heartburn, vomiting, headache, and cold symptoms such as stuffy nose, sneezing, or sinus pain.

Both Ibsrela and Linzess may interact with other drugs.

What Are Possible Side Effects of Ibsrela?

Common side effects of Ibsrela include:

  • diarrhea,
  • abdominal distension,
  • gas (flatulence), and
  • dizziness.

What Are Possible Side Effects of Linzess?

Common side effects of Linzess include:

  • diarrhea,
  • stomach/abdominal pain or discomfort,
  • gas,
  • bloating,
  • heartburn,
  • vomiting,
  • headache, or
  • cold symptoms such as stuffy nose, sneezing, or sinus pain.

What Is Ibsrela?

Ibsrela (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor indicated for treatment of irritable bowel syndrome with constipation (IBS-C) in adults.

What Is Linzess?

Linzess (linaclotide) is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

 

What Drugs Interact With Ibsrela?

Ibsrela may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Ibsrela; maternal use is not expected to result in fetal exposure to the drug. It is unknown if Ibsrela passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Linzess?

Linzess may interact with other drugs.

 

How Should Ibsrela Be Taken?

The recommended dosage of Ibsrela in adults is 50 mg, orally twice daily.

How Should Linzess Be Taken?

The recommended dose of Linzess for those with irritable bowel syndrome (IBS) is 290 mcg taken once a day on an empty stomach, at least 30 minutes before the first meal of the day. The same applies for those with chronic idiopathic constipation only the dosage is 145 mcg. Pediatric patients under the age of 17 should not take Linzess.