Humulin R vs. Lyumjev

Humulin R (insulin [human recombinant]) and Lyumjev (insulin glargine [rdna origin]) Injection are forms of insulin indicated as adjuncts to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus. Humulin R is a short-acting form of insulin and Lyumjev is a long-acting form of insulin.

Side effects of Humulin R and Lyumjev that are similar include low blood sugar (hypoglycemia) (symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, and seizures [severe hypoglycemia can be fatal]) and injection site reactions (e.g., pain, redness, irritation).

Both Humulin R and Lyumjev may interact with albuterol, clonidine, reserpine, and beta-blockers.

Common side effects of Humulin R include:

• injection site reactions (e.g., pain, redness, irritation).

Low blood sugar (hypoglycemia) is the most common side effect of Humulin R.

Symptoms of low blood sugar include:

• headache,
• hunger,
• weakness,
• sweating,
• tremors,
• irritability,
• trouble concentrating,
• rapid breathing,
• fast heartbeat,
• fainting, or
• seizure (severe hypoglycemia can be fatal).

Tell your doctor if you have serious side effects of Humulin R including:

• signs of low potassium level in the blood (such as muscle cramps, weakness, irregular heartbeat).

Side effects of Lyumjev include:

• low blood sugar (hypoglycemia),
• injection site reactions (rash, redness, inflammation, bruising, or itching),
• allergic reactions,
• rash,
• itching,
• changes in body fat distribution (lipodystrophy),
• runny or stuffy nose,
• upper respiratory tract infection, and
• weight gain

Humulin R (insulin (human recombinant)) is a hormone that is produced in the body used to treat diabetes.

Lyumjev (insulin lispro-aabc) is a rapid-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.

Humulin R may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Tell your doctor all medications you are taking.

Lyumjev may interact with other medicines such as:

• antidiabetic agents,
• ACE inhibitors,
• angiotensin II receptor blocking agents (ARBs),
• disopyramide,
• fibrates,
• fluoxetine,
• monoamine oxidase inhibitors (MAOIs),
• pentoxifylline,
• pramlintide,
• salicylates,
• somatostatin analogs (e.g., octreotide),
• sulfonamide antibiotics,
• atypical antipsychotics (e.g., olanzapine and clozapine),
• corticosteroids,
• danazol,
• diuretics (water pills),
• estrogens,
• glucagon,
• isoniazid,
• niacin,
• oral contraceptives,
• phenothiazines,
• progestogens (e.g., in oral contraceptives),
• protease inhibitors,
• somatropin,
• sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline),
• thyroid hormones,
• alcohol,
• beta-blockers,
• clonidine,
• lithium salts,
• guanethidine, and
• reserpine

Tell your doctor all medications and supplements you use.

The recommended starting dose of Humulin R for patients 6 years and older is 25 mg once daily in the morning. The dosage of Humulin R may be increased in increments of 10 to 15 mg at intervals of at least 5 days.

The dosage of Lyumjev is based on the patient’s metabolic needs, glucose monitoring results, and glycemic control goal.