Evenity vs. Reclast

• Are Evenity and Reclast the Same Thing?
• What Are Possible Side Effects of Evenity?
• What Are Possible Side Effects of Reclast?
• What Is Evenity?
• What Is Reclast?
• What Drugs Interact with Evenity?
• What Drugs Interact with Reclast?
• How Should Evenity Be Taken?
• How Should Reclast Be Taken?

Evenity (romosozumab-aqqg) and Reclast (zoledronic acid) are used to treat osteoporosis in postmenopausal women.

Reclast is used to treat or prevent osteoporosis in people who will be taking certain steroid medicines for 12 months or longer.

Reclast is also used to treat Paget's disease, high blood levels of calcium caused by cancer [hypercalcemia of malignancy, multiple myeloma (a type of bone marrow cancer)], or cancer that has spread from elsewhere in the body to the bone, and to increase bone mass in men with osteoporosis.

Evenity and Reclast belong to different drug classes. Evenity is a sclerostin inhibitor and Reclast is a bisphosphonate.

Side effects of Evenity and Reclast that are similar include joint pain, headache, and muscle spasms or pain.

Side effects of Evenity that are different from Reclast include swelling of extremities, weakness, neck pain, insomnia, and numbness and tingling sensation.

Side effects of Reclast that are different from Evenity include nausea, tiredness, flu-like symptoms (e.g., fever, chills, muscle/joint aches), cough, dizziness, vision problems, diarrhea, constipation, and injection site reactions (pain, redness, swelling).

Evenity may interact with other drugs.

Reclast may interact with diuretics (water pills), antibiotics, other medicines that can harm your kidneys, cancer medicines, and nonsteroidal anti-inflammatory drugs (NSAIDs).

Common side effects of Evenity include:

• joint pain,
• headache,
• muscle spasms,
• swelling of extremities,
• weakness,
• neck pain,
• insomnia,
• numbness and
• tingling sensation

Common side effects of Reclast include:

• nausea,
• tiredness,
• flu-like symptoms (e.g., fever, chills, muscle/joint aches),
• cough,
• dizziness,
• headache,
• vision problems,
• diarrhea,
• constipation,
• joint or muscle pain, or
• injection site reactions (pain, redness, swelling).

Evenity (romosozumab-aqqg) is a sclerostin inhibitor indicated for the treatment of osteoporosis in postmenopausal women at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy.

Reclast is a prescription medicine used to:

• Treat or prevent osteoporosis in women after menopause. Reclast helps reduce the chance of having a hip or spinal fracture (break).
• Increase bone mass in men with osteoporosis.
• Treat or prevent osteoporosis in either men or women who will be taking corticosteroid medicines for at least one year.
• Treat certain men and women who have Paget's disease of the bone.

It is not known how long Reclast works for the treatment and prevention of osteoporosis. You should see your doctor regularly to determine if Reclast is still right for you.

Reclast is not for use in children.

Evenity may interact with digoxin. Tell your doctor all medication

Evenity may interact with other drugs. Tell your doctor all medications and supplements you use. Evenity is not recommended for use in women of reproductive potential so it is not intended for use by women who are pregnant or breastfeeding.

Reclast may interact with different drugs. Reclast may interact with diuretics (water pills), antibiotics, other medicines that can harm your kidneys, cancer medicines, or nonsteroidal anti-inflammatory drugs (NSAIDs).

A healthcare provider can administer 210 mg Evenity subcutaneously once every month for 12 doses in the abdomen, thigh, or upper arm. Two separate subcutaneous injections are needed to administer the total dose of 210 mg Evenity.

• Your doctor will tell you how often you will receive Reclast.
• Reclast is given by infusion into your vein (intravenously). Your infusion should last at least 15 minutes.
• Before you receive Reclast, drink at least 2 glasses of fluid (such as water) within a few hours as directed by your doctor.
• You may eat before your treatment with Reclast.
• If you miss a dose of Reclast, call your doctor or healthcare provider to schedule your next dose.