Combivent Respimat vs. DuoNeb

Combivent Respimat (ipratropium bromide and albuterol) Inhalation Spray and DuoNeb (ipratropium bromide and albuterol sulfate) are combinations of bronchodilators used to treat chronic obstructive pulmonary disease (COPD).

Side effects of Combivent Respimat and DuoNeb that are similar include headache, cold symptoms (stuffy nose, sneezing, cough, or sore throat), nausea, and nervousness.

Side effects of Combivent Respimat that are different from DuoNeb include flu-like symptoms, vomiting, difficulty breathing, urinary retention, and fast or irregular heartbeat.

Side effects of DuoNeb that are different from Combivent Respimat include dizziness, dry mouth, shaking (tremors), and constipation.

Both Combivent Respimat and DuoNeb may interact with diuretics (water pills), heart or blood pressure medications, and antidepressants.

Combivent Respimat may also interact with other bronchodilators, bladder or urinary medicines, medications for Parkinson's disease, stimulants, ADHD medications, diet pills, over-the-counter cold or allergy medicine, and medications to treat excess stomach acid, stomach ulcers, motion sickness, or irritable bowel syndrome.

DuoNeb may also interact with other beta-blockers.

Common side effects of Combivent Respimat include:

• headache,
• cold symptoms (stuffy nose, sneezing, cough, or sore throat),
• flu-like symptoms,
• nausea,
• vomiting,
• nervousness,
• difficulty breathing,
• urinary retention and
• fast or irregular heartbeat.

Serious side effects of Combivent Respimat include:

• bronchospasms,
• eye (ocular) changes, and
• heart (cardiac) complications.

Common side effects of DuoNeb include:

• headache,
• dizziness,
• nausea,
• dry mouth,
• shaking (tremors),
• nervousness,
• constipation, or
• cold symptoms such as stuffy nose, sneezing, cough, or sore throat.

Tell your doctor if you have serious side effects of DuoNeb including:

• difficult or painful urination, or
• muscle cramps.

Combivent Respimat (sunitinib malate) is a multi-kinase inhibitor indicated for the treatment of gastrointestinal stromal tumor after disease progression on, or intolerance to imatinib mesylate, for advanced renal cell carcinoma, and for progressive, well-differentiated pancreatic neuroendocrine tumors in patients with unresectable, locally advanced or metastatic disease. Combivent Respimat is available in generic form.

DuoNeb (ipratropium bromide and albuterol sulfate) is a combination of bronchodilators used to treat and prevent symptoms (wheezing and shortness of breath) caused by ongoing lung disease (chronic obstructive pulmonary disease-COPD which includes bronchitis and emphysema).

Combivent Respimat may interact with bladder or urinary medicines, diuretics (water pills), heart or blood pressure medications, medications for Parkinson's disease or depression, other bronchodilators, stimulants, ADHD medications, diet pills, over-the-counter cold or allergy medicine, or medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome. Tell your doctor all medications and supplements you use.

DuoNeb may interact with certain beta-blockers, such as propranolol. Drug interactions may change how your medications work or increase your risk for serious side effects. Tell your doctor all the products you use, including prescription/nonprescription drugs and herbal products.

The Combivent Respimat inhaler delivers 20 mcg of ipratropium bromide (monohydrate) and 100 mcg albuterol (equivalent to 120 mcg albuterol sulfate) from the mouthpiece. The recommended dose of Combivent Respimat is one inhalation four times a day. Patients may take additional inhalations as required; however, the total number of inhalations should not exceed six within 24 hours.

The recommended dose of DuoNeb is one 3 mL vial administered 4 times per day via nebulization with up to 2 additional 3 mL doses allowed per day, if needed.