Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Frasier syndrome
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Frasier syndrome: A condition characterized by the presence of an XY sex chromosome constitution and undermasculinized external genitalia that may range from ambiguous in appearance to normal-looking female genitalia. There is also kidney disease (glomerulosclerosis) and gonadal tumors (gonadoblastoma). Frasier syndrome is caused by point mutations in the WT1 gene (in the intron 9 donor splice site).