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Definition of Glutathione S-transferase omega-1
Medically reviewed by Min Clinic Staff | Updated: January 2026
Glutathione S-transferase omega-1: An enzyme that remarkably influences the age of onset of symptoms of two common degenerative brain disorders -- both Alzheimer disease and Parkinson disease.
Glutathione S-transferase omega-1 (GSTO1) belongs to a family of enzymes that utilize glutathione in reactions contributing to the transformation of a wide range of compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. The gene encoding GSTO1 is on chromosome 10. Also written: Glutathione S-transferase, omega-1.