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Definition of Glutathione S-transferase
Medically reviewed by Min Clinic Staff | Updated: January 2026
Glutathione S-transferase: A family of enzymes that utilize glutathione in reactions contributing to the transformation of a wide range of compounds, including carcinogens, therapeutic drugs, and products of oxidative stress.
The glutathione S-transferases act by catalyzing the reaction of glutathione with an acceptor molecule to form an S-substituted glutathione (S = sulfur). See also: Glutathione S-transferase omega-1.