Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Fissure
Medically reviewed by Min Clinic Staff | Updated: January 2026
Fissure: A cleft or groove. A fissure can be normal or abnormal.
A fissure in the cerebral cortex is a normal feature. It is a deep fold that involves the entire thickness of the brain wall.
A fissure in the anus is abnormal. It is a painful crack in the edge of the anus and is very painful. Also called an anal fissure or fissure in ano.