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Definition of Genome, chromosomal
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Genome, chromosomal: All of the genetic information in the chromosomes of an organism. For humans, that is all of the DNA contained in our normal complement of 46 rod-like chromosomes in virtually every cell in the body. (Mature red blood cells, for one exception, have no nucleus and therefore no chromosomes). The chromosomal genome is synonymous with the nuclear genome. Together with the mitochondrial genome, it constitutes the genome of the human being.