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Definition of Gene-expression profiling
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Gene-expression profiling: A genomic technique that based on the fact that only a fraction of the genes encoded in the genome of a cell are expressed by being transcribed into messenger RNA (mRNA). The complement of mRNAs in a cell largely dictates its complement of proteins. Consequently, gene expression is a major determinant of the biology of both normal and malignant cells.