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Definition of Gene amplification
Medically reviewed by Min Clinic Staff | Updated: January 2026
Gene amplification: Making multiple copies of a gene. Repeated copying of a gene.
Gene amplification plays a role in cancer cells. A tumor cell amplifies, or copies, DNA segments as a result of cell signals and sometimes environmental events.
Amplification can occur in vivo (in the living individual) or in vitro (literally "in glass", or in a plastic vessel in the laboratory).