Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.

Definition of CpG island

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

CpG island: In molecular genetics, a short region of DNA rich in CpG sites, often located near the promoters of genes. Methylation of the CpG sites influences the activity of nearby genes and is critical to the regulation of gene expression.

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