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Definition of Disease, subclinical

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Disease, subclinical: An illness that stays "below the surface" of clinical detection. A subclinical disease has no or minimally recognizable clinical findings. It is distinct from a clinical disease, which has signs and symptoms that can be more easily recognized. Many diseases, including diabetes, hypothyroidism, rheumatoid arthritis, infections or cancers can be subclinical before surfacing as clinical diseases.