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Definition of Endostatin
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Endostatin: A fragment of a protein, collagen 18, that is found in all blood vessels. Endostatin is normally secreted by blood vessels in response to tumors. Endostatin appears to halt the process of developing new blood vessels (angiogenesis), which is necessary to tumor development.