Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Endoderm
Medically reviewed by Min Clinic Staff | Updated: January 2026
Endoderm: One of the three primary germ cell layers -- the other two are the mesoderm and ectoderm -- in the very early embryo. The endoderm is the innermost of the three layers. It differentiates to give rise first to the embryonic gut and then to the linings of respiratory and digestive tracts and the liver and pancreas.