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Definition of Antisense mRNA
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Antisense mRNA: An mRNA (messenger RNA) transcript that is complementary to endogenous mRNA. Antisense mRNA is the noncoding strand complementary to the coding sequence of mRNA. Introducing a transgene coding for antisense mRNA is a strategy used to block expression of a gene of interest.