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Definition of Discordance

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Discordance: 1. The presence of any given condition such as HIV in only one member of a couple. 2. In genetics, the presence of a phenotype such as asthma in only one members of a twin pair. 3. In clinical care, lack of agreement between physician and patient.
In all sense, disconcordance is as opposed to concordance. From dis- + the Latin concordare, to agree = not to agree.